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mes-3 Polycomb protein mes-3 [ Caenorhabditis elegans ]

Gene ID: 172123, updated on 2-Nov-2024

Summary

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Official Symbol
mes-3
Official Full Name
Polycomb protein mes-3
Primary source
WormBase:WBGene00003221
Locus tag
CELE_F54C1.3
See related
AllianceGenome:WB:WBGene00003221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of gene expression. Located in nucleus. Part of PcG protein complex and nucleosome. Is expressed in several structures, including AB; C; D; E; and germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mes-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (4996835..5003202)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CILiary localization Neighboring gene Tetratricopeptide repeat protein 30 homolog Neighboring gene Decapping nuclease dom-3 Neighboring gene Uncharacterized protein Neighboring gene Sperm Specific Transcript

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans. Bender LB, et al. Curr Biol, 2004 Sep 21. PMID 15380065
  2. Chromatin domains rich in inheritance. Reinberg D, et al. Science, 2018 Jul 6. PMID 29976815
  3. The onset of C. elegans dosage compensation is linked to the loss of developmental plasticity. Custer LM, et al. Dev Biol, 2014 Jan 15. PMID 24252776, Free PMC Article
  4. Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Fong Y, et al. Science, 2002 Jun 21. PMID 12077420, Free PMC Article
  5. The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Korf I, et al. Development, 1998 Jul. PMID 9609830

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mes-3 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration.
    Title: Polycomb group regulation of Hox gene expression in C. elegans.
  2. mes-3 mutants suppress mab-3.
    Title: Finally, worm polycomb-like genes meet Hox regulation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Polycomb protein mes-3
NP_001021492.1
  • Confirmed by transcript evidence
NP_001361974.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4996835..5003202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001374884.2 → NP_001361974.1  Polycomb protein mes-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY65

  2. NM_001026321.4 → NP_001021492.1  Polycomb protein mes-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021492.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91324, Q10665
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10665.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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