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dom-3 Decapping nuclease dom-3 [ Caenorhabditis elegans ]

Gene ID: 172124, updated on 2-Nov-2024

Summary

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Official Symbol
dom-3
Official Full Name
Decapping nuclease dom-3
Primary source
WormBase:WBGene00001050
Locus tag
CELE_F54C1.2
See related
AllianceGenome:WB:WBGene00001050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA 5'-diphosphatase activity. Predicted to be involved in NAD-cap decapping and nuclear-transcribed mRNA catabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dom-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (5003450..5004933)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 30 homolog Neighboring gene Polycomb protein mes-3 Neighboring gene Uncharacterized protein Neighboring gene Sperm Specific Transcript Neighboring gene glucuronosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans. Shen Y, et al. J Neurosci, 2014 Oct 1. PMID 25274815, Free PMC Article
  2. Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans. Paulsen JE, et al. Genetics, 1995 Dec. PMID 8601481, Free PMC Article
  3. Trans-splicing and polycistronic transcription in Caenorhabditis elegans. Blumenthal T. Trends Genet, 1995 Apr. PMID 7732590
  4. Caenorhabditis elegans operons: form and function. Blumenthal T, et al. Nat Rev Genet, 2003 Feb. PMID 12560808
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA NAD+-cap (NAD+-forming) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD-cap decapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Decapping nuclease dom-3
NP_491496.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5003450..5004933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059095.8 → NP_491496.1  Decapping nuclease dom-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491496.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10660
    Conserved Domains (1) summary
    pfam08652
    Location:266 → 315
    RAI1; RAI1 like PD-(D/E)XK nuclease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10660.1

Gene LinkOut

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