U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kin-32 Inactive tyrosine-protein kinase kin-32 [ Caenorhabditis elegans ]

Gene ID: 172135, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
kin-32
Official Full Name
Inactive tyrosine-protein kinase kin-32
Primary source
WormBase:WBGene00002213
Locus tag
CELE_C30F8.4
See related
AllianceGenome:WB:WBGene00002213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cellular component organization; and signal complex assembly. Predicted to be located in cell junction. Predicted to be active in dendritic spine; focal adhesion; and plasma membrane. Is expressed in body wall musculature; head mesodermal cell; head neurons; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kin-32 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (5086310..5093903)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene V-type proton ATPase subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intraflagellar transport protein 20 homolog Neighboring gene V-type proton ATPase subunit B 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. Di Gregorio E, et al. J Med Genet, 2013 Aug. PMID 23749989, Free PMC Article
  2. Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Cram EJ, et al. Dev Dyn, 2008 Mar. PMID 18297732, Free PMC Article
  3. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
  4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables non-membrane spanning protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Inactive tyrosine-protein kinase kin-32
NP_740841.1
  • Confirmed by transcript evidence
NP_740842.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5086310..5093903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170854.6 → NP_740841.1  Inactive tyrosine-protein kinase kin-32 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740841.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T879, Q95YD4
    Conserved Domains (4) summary
    smart00221
    Location:367 → 623
    STYKc; Protein kinase; unclassified specificity
    smart00295
    Location:5 → 230
    B41; Band 4.1 homologues
    cd13190
    Location:226 → 336
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cl21453
    Location:360 → 631
    PKc_like; Protein Kinases, catalytic domain

  2. NM_170855.6 → NP_740842.1  Inactive tyrosine-protein kinase kin-32 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740842.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95YD4
    Conserved Domains (3) summary
    smart00221
    Location:298 → 554
    STYKc; Protein kinase; unclassified specificity
    cd13190
    Location:157 → 267
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cl21453
    Location:291 → 562
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95YD4.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous