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spe-5 V-type proton ATPase subunit B 2 [ Caenorhabditis elegans ]

Gene ID: 172137, updated on 2-Nov-2024

Summary

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Official Symbol
spe-5
Official Full Name
V-type proton ATPase subunit B 2
Primary source
WormBase:WBGene00004959
Locus tag
CELE_Y110A7A.12
See related
AllianceGenome:WB:WBGene00004959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in intracellular pH reduction; positive regulation of programmed cell death; and spermatocyte division. Located in cytoplasm. Is expressed in sperm and spermatocyte. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1) and ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spe-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (5101665..5103476, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inactive tyrosine-protein kinase kin-32 Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intraflagellar transport protein 20 homolog Neighboring gene ncRNA Neighboring gene Cysteine and histidine-rich domain-containing protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans spe-5 gene is required for morphogenesis of a sperm-specific organelle and is associated with an inherent cold-sensitive phenotype. Machaca K, et al. Genetics, 1997 Jun. PMID 9178007, Free PMC Article
  2. Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis. Gleason EJ, et al. Genetics, 2012 Jun. PMID 22446317, Free PMC Article
  3. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Syntichaki P, et al. Curr Biol, 2005 Jul 12. PMID 16005300
  4. Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. L'Hernault SW, et al. Genetics, 1988 Oct. PMID 3197956, Free PMC Article
  5. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatocyte division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit B 2
NP_491518.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5101665..5103476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059117.4 → NP_491518.1  V-type proton ATPase subunit B 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5A0
    Conserved Domains (1) summary
    TIGR01040
    Location:40 → 501
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N5A0.1

Gene LinkOut

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