spd-5 Spindle-defective protein 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spd-5
Official Full Name: Spindle-defective protein 5
Primary source: WormBase:WBGene00004955
Locus tag: CELE_F56A3.4
See related: AllianceGenome:WB:WBGene00004955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spd-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (5171285..5176654, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
Title: Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
Centrosome maturation requires phosphorylation-mediated sequential domain interactions of SPD-5.
Title: Centrosome maturation requires phosphorylation-mediated sequential domain interactions of SPD-5.
Recruitment of the scaffold component SPD-5 occurs throughout the pericentriolar material (PCM). Incorporation of additional PCM subunits is therefore not limited to specific nucleation sites near centrioles.
Title: Isotropic incorporation of SPD-5 underlies centrosome assembly in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A3.4 (e-PCR)
- UniSTS:311849

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Spindle-defective protein 5

NP_491539.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5171285..5176654 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059138.6 → NP_491539.1 Spindle-defective protein 5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491539.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91349

Conserved Domains (1) summary

COG1196
Location:702 → 1023

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]