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frm-4 FERM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172189, updated on 2-Nov-2024

Summary

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Official Symbol
frm-4
Official Full Name
FERM domain-containing protein
Primary source
WormBase:WBGene00001491
Locus tag
CELE_C24A11.8
See related
AllianceGenome:WB:WBGene00001491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD3 (FERM domain containing 3) and FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See frm-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
19
Sequence:
Chromosome: I; NC_003279.8 (5402884..5412400, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene polynucleotide adenylyltransferase Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Decaprenyl-diphosphate synthase subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Simon DJ, et al. Cell, 2008 May 30. PMID 18510933, Free PMC Article
  2. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM domain-containing protein
NP_001249887.1
  • Confirmed by transcript evidence
NP_001370485.1
  • Confirmed by transcript evidence
NP_491586.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5402884..5412400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001262958.3 → NP_001249887.1  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYZ7
    Conserved Domains (2) summary
    smart00295
    Location:29 → 226
    B41; Band 4.1 homologues
    cl17171
    Location:212 → 346
    PH-like; Pleckstrin homology-like domain

  2. NM_001383090.2 → NP_001370485.1  FERM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q79
    Conserved Domains (2) summary
    smart00295
    Location:29 → 226
    B41; Band 4.1 homologues
    cl17171
    Location:212 → 346
    PH-like; Pleckstrin homology-like domain

  3. NM_059185.8 → NP_491586.1  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYZ6
    Conserved Domains (2) summary
    smart00295
    Location:29 → 218
    B41; Band 4.1 homologues
    cl17171
    Location:204 → 338
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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