U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ceh-12 Homeobox domain-containing protein;Homeobox protein ceh-12 [ Caenorhabditis elegans ]

Gene ID: 172255, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ceh-12
Official Full Name
Homeobox domain-containing protein;Homeobox protein ceh-12
Primary source
WormBase:WBGene00000436
Locus tag
CELE_F33D11.4
See related
AllianceGenome:WB:WBGene00000436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in neuron fate specification. Predicted to be active in nucleus. Is expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ceh-12 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (5840282..5841940)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Oxysterol-binding protein Neighboring gene Potassium channel domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DUF4263 domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and expression in vitro of a gene encoding tRNAArgACG from the nematode Caenorhabditis elegans. Schaller D, et al. Gene, 1991 Jan 15. PMID 1999292
  2. Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans. Schaller D, et al. Nucleic Acids Res, 1990 Apr 25. PMID 1970877, Free PMC Article
  3. UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Schneider J, et al. Development, 2012 Jun. PMID 22619391, Free PMC Article
  4. UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans. Von Stetina SE, et al. Genes Dev, 2007 Feb 1. PMID 17289921, Free PMC Article
  5. Caenorhabditis elegans has scores of homoeobox-containing genes. Bürglin TR, et al. Nature, 1989 Sep 21. PMID 2571091

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Homeobox domain-containing protein;Homeobox protein ceh-12
NP_001309522.1
  • Confirmed by transcript evidence
NP_491693.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5840282..5841940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059292.2 → NP_491693.1  Homeobox protein ceh-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491693.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17487, Q9TZZ7
    Conserved Domains (1) summary
    pfam00046
    Location:113 → 166
    Homeobox; Homeobox domain

  2. NM_001322676.1 → NP_001309522.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MAP5
    Conserved Domains (1) summary
    pfam00046
    Location:4 → 58
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17487.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools