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ari-1.3 RBR-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 172282, updated on 2-Nov-2024

Summary

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Official Symbol
ari-1.3
Official Full Name
RBR-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00016156
Locus tag
CELE_C27A12.6
See related
AllianceGenome:WB:WBGene00016156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ari-1.3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (6053785..6055821, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Homeobox protein ceh-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene E3 ubiquitin-protein ligase ari-1.1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans. Qiu X, et al. Dev Biol, 2006 Mar 15. PMID 16457801
  2. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RBR-type E3 ubiquitin transferase
NP_001379539.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6053785..6055821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392396.1 → NP_001379539.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01963
    Conserved Domains (4) summary
    smart00647
    Location:193 → 253
    IBR; In Between Ring fingers
    cd00162
    Location:126 → 172
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam01485
    Location:274 → 315
    IBR; IBR domain, a half RING-finger domain
    cl17238
    Location:125 → 178
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version

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