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ari-1.1 E3 ubiquitin-protein ligase ari-1.1 [ Caenorhabditis elegans ]

Gene ID: 172284, updated on 2-Nov-2024

Summary

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Official Symbol
ari-1.1
Official Full Name
E3 ubiquitin-protein ligase ari-1.1
Primary source
WormBase:WBGene00016158
Locus tag
CELE_C27A12.8
See related
AllianceGenome:WB:WBGene00016158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line; hermaphrodite gonad; nervous system; non-striated muscle; and rectal gland cell. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ari-1.1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6058548..6060953, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene ncRNA Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene GPI ethanolamine phosphate transferase 3 Neighboring gene Methyl-CpG binding protein 2/3 C-terminal domain-containing protein Neighboring gene Histone H1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A regulatory module controlling pharyngeal development and function in Caenorhabditis elegans. Fay DS, et al. Genetics, 2012 Jul. PMID 22542967, Free PMC Article
  2. Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development. Dove KK, et al. Proc Natl Acad Sci U S A, 2017 Aug 8. PMID 28739890, Free PMC Article
  3. Implicating SCF complexes in organogenesis in Caenorhabditis elegans. Polley SR, et al. Genetics, 2014 Jan. PMID 24214340, Free PMC Article
  4. ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans. Qiu X, et al. Dev Biol, 2006 Mar 15. PMID 16457801
  5. The C. elegans pharynx: a model for organogenesis. Mango SE. WormBook, 2007 Jan 22. PMID 18050503, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ari-1.1
NP_491749.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6058548..6060953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059348.7 → NP_491749.2  E3 ubiquitin-protein ligase ari-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491749.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01965
    Conserved Domains (4) summary
    smart00647
    Location:196 → 255
    IBR; In Between Ring fingers
    cd00162
    Location:128 → 174
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam01485
    Location:276 → 317
    IBR; IBR domain, a half RING-finger domain
    cl17238
    Location:127 → 180
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01965.3

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