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nse-1 Phorbol-ester/DAG-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172295, updated on 2-Nov-2024

Summary

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Official Symbol
nse-1
Official Full Name
Phorbol-ester/DAG-type domain-containing protein
Primary source
WormBase:WBGene00020843
Locus tag
CELE_T27A3.7
See related
AllianceGenome:WB:WBGene00020843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nse-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (6107817..6109655, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Molybdopterin synthase catalytic subunit Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene HAP1 N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of NSE-4 Perturbs Genome Stability and DNA Repair in Caenorhabditis elegans. Odiba AS, et al. Int J Mol Sci, 2022 Jun 29. PMID 35806213, Free PMC Article
  2. Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis. Odiba AS, et al. Genetics, 2023 Oct 4. PMID 37579186, Free PMC Article
  3. SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans. Odiba AS, et al. DNA Repair (Amst), 2024 May. PMID 38507953
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phorbol-ester/DAG-type domain-containing protein
NP_491764.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6107817..6109655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059363.6 → NP_491764.1  Phorbol-ester/DAG-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491764.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91501
    Conserved Domains (1) summary
    cl00040
    Location:241 → 275
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
Nucleotide Protein
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