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usp-5 Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

Gene ID: 172296, updated on 2-Nov-2024

Summary

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Official Symbol
usp-5
Official Full Name
Ubiquitin carboxyl-terminal hydrolase
Primary source
WormBase:WBGene00020839
Locus tag
CELE_T27A3.2
See related
AllianceGenome:WB:WBGene00020839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13) and USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See usp-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (6110134..6114549)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Molybdopterin synthase catalytic subunit Neighboring gene Phorbol-ester/DAG-type domain-containing protein Neighboring gene HAP1 N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
  2. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
  3. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquitin carboxyl-terminal hydrolase
NP_001391078.1
  • Confirmed by transcript evidence
NP_491765.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6110134..6114549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059364.8 → NP_491765.2  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491765.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91502
    Conserved Domains (5) summary
    COG5207
    Location:19 → 788
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:320 → 786
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14296
    Location:597 → 634
    UBA1_scUBP14_like; UBA1 domain found in Saccharomyces cerevisiae ubiquitin carboxyl-terminal hydrolase 14 (scUBP14) and similar proteins
    cd14327
    Location:660 → 695
    UBA_atUPL1_2_like; UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins
    pfam02148
    Location:185 → 266
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. NM_001404186.1 → NP_001391078.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I6U5
Nucleotide Protein
Heading Accession and Version

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