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pept-3 Peptide transporter 3 [ Caenorhabditis elegans ]

Gene ID: 172298, updated on 2-Nov-2024

Summary

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Official Symbol
pept-3
Official Full Name
Peptide transporter 3
Primary source
WormBase:WBGene00003878
Locus tag
CELE_F56F4.5
See related
AllianceGenome:WB:WBGene00003878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables dipeptide transmembrane transporter activity and proton channel activity. Involved in dipeptide transport and proton transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in AVAL; AVAR; pharynx; and touch receptor neurons. Orthologous to human SLC15A1 (solute carrier family 15 member 1) and SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pept-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (6133245..6137977)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HAP1 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Tyr Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Transposase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons. Fei YJ, et al. J Biol Chem, 2000 Mar 31. PMID 10734106
  2. A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span. Nehrke K. J Biol Chem, 2003 Nov 7. PMID 12939266
  3. Differential adhesion regulates neurite placement via a retrograde zippering mechanism. Sengupta T, et al. Elife, 2021 Nov 16. PMID 34783657, Free PMC Article
  4. The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes. Wightman B, et al. Dev Biol, 2005 Nov 1. PMID 16183052
  5. zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans. Wacker I, et al. Development, 2003 Aug. PMID 12835395

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oligopeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proton channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dipeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptide transporter 3
NP_491767.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6133245..6137977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059366.8 → NP_491767.3  Peptide transporter 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491767.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01840, Q9NJH8
    Conserved Domains (2) summary
    TIGR00926
    Location:29 → 664
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:82 → 449
    PTR2; POT family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01840.1

Gene LinkOut

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