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tin-44 putative mitochondrial import inner membrane translocase subunit tin-44 [ Caenorhabditis elegans ]

Gene ID: 172302, updated on 18-Sep-2024

Summary

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Official Symbol
tin-44
Official Full Name
putative mitochondrial import inner membrane translocase subunit tin-44
Primary source
WormBase:WBGene00020383
Locus tag
CELE_T09B4.9
See related
AllianceGenome:WB:WBGene00020383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chaperone binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in intestine; nervous system; pharynx; reproductive system; and tail. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tin-44 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (6177934..6180840, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase CHIP Neighboring gene Torsin-1B Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
  2. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  3. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
  4. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
  5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative mitochondrial import inner membrane translocase subunit tin-44
NP_491780.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6177934..6180840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059379.5 → NP_491780.1  putative mitochondrial import inner membrane translocase subunit tin-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491780.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02161
    Conserved Domains (4) summary
    TIGR00984
    Location:44 → 415
    3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
    pfam04280
    Location:269 → 418
    Tim44; Tim44-like domain
    cl12013
    Location:37 → 111
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23763
    Location:96 → 174
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02161.1

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