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T05E7.3 WASH complex subunit strumpellin [ Caenorhabditis elegans ]

Gene ID: 172306, updated on 2-Nov-2024

Summary

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Official Symbol
T05E7.3
Official Full Name
WASH complex subunit strumpellin
Primary source
WormBase:WBGene00020259
Locus tag
CELE_T05E7.3
See related
AllianceGenome:WB:WBGene00020259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in several processes, including actin filament polymerization; endosome fission; and regulation of actin nucleation. Predicted to be part of WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T05E7.3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (6188153..6192632)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Torsin-1B Neighboring gene ncRNA Neighboring gene GPI mannosyltransferase pigv-1 Neighboring gene DUF7027 domain-containing protein Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WASH complex subunit strumpellin
NP_491784.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6188153..6192632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059383.6 → NP_491784.1  WASH complex subunit strumpellin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01858
    Conserved Domains (1) summary
    pfam10266
    Location:18 → 958
    Strumpellin; Hereditary spastic paraplegia protein strumpellin
Nucleotide Protein
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