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klu-2 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172339, updated on 2-Nov-2024

Summary

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Official Symbol
klu-2
Official Full Name
C2H2-type domain-containing protein
Primary source
WormBase:WBGene00022592
Locus tag
CELE_ZC328.2
See related
AllianceGenome:WB:WBGene00022592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZNF740 (zinc finger protein 740). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See klu-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (6386149..6394350, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein;Poly(A) RNA polymerase gld-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein cuti-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Vavouri T, et al. Cell, 2009 Jul 10. PMID 19596244
  2. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C2H2-type domain-containing protein
NP_491843.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6386149..6394350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059442.8 → NP_491843.3  C2H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491843.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02050
    Conserved Domains (3) summary
    COG5048
    Location:216 → 298
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249 → 269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:262 → 286
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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