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dbr-1 Lariat debranching enzyme [ Caenorhabditis elegans ]

Gene ID: 172357, updated on 2-Nov-2024

Summary

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Official Symbol
dbr-1
Official Full Name
Lariat debranching enzyme
Primary source
WormBase:WBGene00000937
Locus tag
CELE_C55B7.8
See related
AllianceGenome:WB:WBGene00000937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dbr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (6490716..6492727, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chromo domain-containing protein Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 18 Neighboring gene Unconventional prefoldin RPB5 interactor Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation. Nam K, et al. Mol Cell Biol, 1997 Feb. PMID 9001235, Free PMC Article
  2. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
  3. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  4. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
  5. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA lariat debranching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA lariat debranching enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA lariat debranching enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing, via transesterification reactions ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Lariat debranching enzyme
NP_491868.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6490716..6492727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059467.6 → NP_491868.2  Lariat debranching enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491868.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90972, Q966M6
    Conserved Domains (3) summary
    cd00844
    Location:43 → 311
    MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
    pfam00149
    Location:41 → 277
    Metallophos; Calcineurin-like phosphoesterase
    pfam05011
    Location:293 → 428
    DBR1; Lariat debranching enzyme, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q966M6.2

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