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spg-20 Inheritance of peroxisomes protein 1 [ Caenorhabditis elegans ]

Gene ID: 172369, updated on 2-Nov-2024

Summary

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Official Symbol
spg-20
Official Full Name
Inheritance of peroxisomes protein 1
Primary source
WormBase:WBGene00019006
Locus tag
CELE_F57B10.9
See related
AllianceGenome:WB:WBGene00019006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in cell division and negative regulation of BMP signaling pathway. Predicted to be located in peroxisomal membrane. Predicted to be extrinsic component of intraperoxisomal membrane. Predicted to be active in plasma membrane. Is expressed in body wall musculature and nervous system. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spg-20 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (6550536..6552625, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Activator of basal transcription 1 Neighboring gene Cytochrome b-c1 complex subunit 10 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidative Stress in Caenorhabditis elegans: Protective Effects of Spartin. Truong T, et al. PLoS One, 2015. PMID 26114733, Free PMC Article
  2. An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons. De Stasio EA, et al. Genetics, 2018 Mar. PMID 29301909, Free PMC Article
  3. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome inheritance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extrinsic component of intraperoxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Inheritance of peroxisomes protein 1
NP_491888.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6550536..6552625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059487.7 → NP_491888.2  Inheritance of peroxisomes protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491888.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44735
    Conserved Domains (3) summary
    cd02679
    Location:14 → 90
    MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
    pfam06911
    Location:262 → 436
    Senescence; Senescence-associated protein
    pfam12634
    Location:117 → 237
    Inp1; Inheritance of peroxisomes protein 1
Nucleotide Protein
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