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dad-1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 [ Caenorhabditis elegans ]

Gene ID: 172370, updated on 2-Nov-2024

Summary

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Official Symbol
dad-1
Official Full Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
Primary source
WormBase:WBGene00000896
Locus tag
CELE_F57B10.10
See related
AllianceGenome:WB:WBGene00000896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dad-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (6553481..6554290, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inheritance of peroxisomes protein 1 Neighboring gene Cytochrome b-c1 complex subunit 10 Neighboring gene ncRNA Neighboring gene Trehalase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. Sugimoto A, et al. EMBO J, 1995 Sep 15. PMID 7556086, Free PMC Article
  2. Programmed cell death in invertebrates. Hengartner MO. Curr Opin Genet Dev, 1996 Feb. PMID 8791487
  3. Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Hengartner MO. Exp Gerontol, 1997 Jul-Oct. PMID 9315441
  4. Programmed cell death. Conradt B, et al. WormBook, 2005 Oct 6. PMID 18061982, Free PMC Article
  5. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
NP_491889.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6553481..6554290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059488.7 → NP_491889.1  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491889.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52872
    Conserved Domains (1) summary
    pfam02109
    Location:8 → 113
    DAD; DAD family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52872.1

Gene LinkOut

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