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mei-2 Meiotic spindle formation protein 2 [ Caenorhabditis elegans ]

Gene ID: 172374, updated on 2-Nov-2024

Summary

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Official Symbol
mei-2
Official Full Name
Meiotic spindle formation protein 2
Primary source
WormBase:WBGene00003184
Locus tag
CELE_F57B10.12
See related
AllianceGenome:WB:WBGene00003184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Contributes to microtubule severing ATPase activity. Involved in embryo development; meiotic spindle organization; and microtubule depolymerization. Located in cytoplasm; nucleus; and spindle pole. Part of katanin complex. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mei-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (6564749..6565852, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GOLD domain-containing protein Neighboring gene BAG family molecular chaperone regulator 1 Neighboring gene Protein MRVI1;Thyroid receptor-interacting protein 11 Neighboring gene 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing. Szczesna E, et al. Dev Cell, 2022 Nov 7. PMID 36347241, Free PMC Article
  2. Cellular Samurai: katanin and the severing of microtubules. Quarmby L. J Cell Sci, 2000 Aug. PMID 10910766
  3. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Vemu A, et al. Science, 2018 Aug 24. PMID 30139843, Free PMC Article
  4. Structural basis for disassembly of katanin heterododecamers. Nithianantham S, et al. J Biol Chem, 2018 Jul 6. PMID 29752405, Free PMC Article
  5. Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly. Joly N, et al. Development, 2016 Oct 1. PMID 27578779

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans.
    Title: Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans.
  2. Purified MEI-1/MEI-2 complexes preferentially sever at intersections between two microtubules and directly bundle microtubules in vitro.
    Title: Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to microtubule severing ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of katanin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Meiotic spindle formation protein 2
NP_491894.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6564749..6565852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059493.8 → NP_491894.1  Meiotic spindle formation protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44740
    Conserved Domains (1) summary
    pfam13925
    Location:161 → 253
    Katanin_con80; con80 domain of Katanin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44740.1

Gene LinkOut

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