lbp-6 Fatty acid-binding protein homolog 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lbp-6
Official Full Name: Fatty acid-binding protein homolog 6
Primary source: WormBase:WBGene00002258
Locus tag: CELE_W02D3.5
See related: AllianceGenome:WB:WBGene00002258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G; hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including FABP12 (fatty acid binding protein 12); FABP3 (fatty acid binding protein 3); and FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lbp-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (6728296..6729376, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02D3.5 (e-PCR)
- UniSTS:317225

W02D3.6 (e-PCR)
- UniSTS:311091

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Fatty acid-binding protein homolog 6

NP_491926.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6728296..6729376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059525.7 → NP_491926.1 Fatty acid-binding protein homolog 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491926.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01812

Conserved Domains (1) summary

pfam00061
Location:6 → 122

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family