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unc-87 Protein unc-87 [ Caenorhabditis elegans ]

Gene ID: 172397, updated on 2-Nov-2024

Summary

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Official Symbol
unc-87
Official Full Name
Protein unc-87
Primary source
WormBase:WBGene00006819
Locus tag
CELE_F08B6.4
See related
AllianceGenome:WB:WBGene00006819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and myosin binding activity. Involved in actin cytoskeleton organization and negative regulation of muscle filament sliding. Located in I band; stress fiber; and striated muscle thin filament. Part of actomyosin, myosin complex part. Is expressed in several structures, including non-striated muscle; pharynx; spermatheca; ventral ganglion; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-87 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6761221..6767797, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G protein gamma domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene BPH_3 domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle. Goetinck S, et al. J Cell Biol, 1994 Oct. PMID 7929572, Free PMC Article
  2. UNC-87 is an actin-bundling protein. Kranewitter WJ, et al. J Biol Chem, 2001 Mar 2. PMID 11096113
  3. The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeats. Lener T, et al. FEBS Lett, 2004 Jan 2. PMID 14706854
  4. Segregated localization of two calponin-related proteins within sarcomeric thin filaments in Caenorhabditis elegans striated muscle. Ono S. Cytoskeleton (Hoboken), 2024 Feb-Mar. PMID 37792405, Free PMC Article
  5. Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction. Ono S, et al. J Biol Chem, 2020 Aug 21. PMID 32554465, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction.
    Title: Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction.
  2. Both UNC-87 isoforms bind to actin filaments and myosin to induce ATP-resistant actomyosin bundles and inhibit actomyosin motility.
    Title: UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.
  3. Data show that UNC-87 competes with ADF/cofilin (unc-60) for binding to actin filaments and inhibits ADF/cofilin-dependent filament severing and depolymerization in vitro.
    Title: UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeletal motor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myosin filament assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of muscle filament sliding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of muscle filament sliding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in I band IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of actomyosin, myosin complex part IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein unc-87
NP_001021092.1
  • Confirmed by transcript evidence
NP_001021093.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6761221..6767797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025921.5 → NP_001021092.1  Protein unc-87 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P37806, Q6EZG6, Q9TYS6
    Conserved Domains (1) summary
    pfam00402
    Location:434 → 454
    Calponin; Calponin family repeat

  2. NM_001025922.6 → NP_001021093.1  Protein unc-87 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6LD30
    Conserved Domains (1) summary
    pfam00402
    Location:243 → 263
    Calponin; Calponin family repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37806.3

Gene LinkOut

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