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ztf-4 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172422, updated on 2-Nov-2024

Summary

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Official Symbol
ztf-4
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00020399
Locus tag
CELE_T10B11.3
See related
AllianceGenome:WB:WBGene00020399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Is expressed in several structures, including gonadal primordium; head; midbody; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including RALYL (RALY RNA binding protein like); RALY (RALY heterogeneous nuclear ribonucleoprotein); and HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ztf-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (6926257..6929665)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein 15 Neighboring gene Transmembrane protein Neighboring gene Ceramide kinase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
  2. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Xu L, et al. Nature, 2003 Sep 18. PMID 13679922
  3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
RRM domain-containing protein
NP_491976.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6926257..6929665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059575.5 → NP_491976.2  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491976.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZI2
    Conserved Domains (2) summary
    COG0724
    Location:64 → 272
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:83 → 151
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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