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nuo-6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [ Caenorhabditis elegans ]

Gene ID: 172438, updated on 2-Nov-2024

Summary

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Official Symbol
nuo-6
Official Full Name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Primary source
WormBase:WBGene00012166
Locus tag
CELE_W01A8.4
See related
AllianceGenome:WB:WBGene00012166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane and mitochondrion. Predicted to be part of respiratory chain complex I. Is expressed in body wall musculature; germ line; gonad; hypodermis; and intestine. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nuo-6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (7068116..7069186, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pharynx mitochondrial [Ca(2+)] dynamics in live C. elegans worms during aging. Alvarez-Illera P, et al. Oncotarget, 2017 Aug 22. PMID 28915560, Free PMC Article
  2. Long-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor. Alvarez-Illera P, et al. Oncotarget, 2016 Oct 18. PMID 27661127, Free PMC Article
  3. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. Yang W, et al. PLoS Biol, 2010 Dec 7. PMID 21151885, Free PMC Article
  4. Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant. Pujol C, et al. PLoS One, 2013. PMID 23555681, Free PMC Article
  5. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Yee C, et al. Cell, 2014 May 8. PMID 24813612, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROS production by mitochondrial mutants and found that isp-1 and nuo-6 mutants have increased generation of the superoxide anion but not increased levels of other ROS and that this increase is necessary and sufficient for longevity.
    Title: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
  2. found that the lifespan increase induced by nuo-6(RNAi) is fully additive to that induced by isp-1(qm150), and the increase induced by isp-1(RNAi) is fully additive to that induced by nuo-6(qm200)[nuo-6]
    Title: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.
  3. The GCN-2 pathway was not required for the longevity phenotype of nuo-6 worms.
    Title: The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
NP_492001.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7068116..7069186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059600.6 → NP_492001.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492001.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23098
    Conserved Domains (1) summary
    pfam07225
    Location:39 → 155
    NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
Nucleotide Protein
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