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gly-18 GLYcosylation related [ Caenorhabditis elegans ]

Gene ID: 172446, updated on 2-Nov-2024

Summary

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Official Symbol
gly-18
Official Full Name
GLYcosylation related
Primary source
WormBase:WBGene00001643
Locus tag
CELE_F22D6.11
See related
AllianceGenome:WB:WBGene00001643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Is expressed in several structures, including GLR; distal tip cell; enteric muscle; ventral nerve cord; and vm1. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type); and GCNT4 (glucosaminyl (N-acetyl) transferase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gly-18 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (7110234..7112443)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Inner membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues. Warren CE, et al. Glycobiology, 2001 Nov. PMID 11744632
  2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GLYcosylation related
NP_492014.4
  • Product from WormBase gene class gly;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7110234..7112443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059613.5 → NP_492014.4  GLYcosylation related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492014.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19730, Q962C3
    Conserved Domains (1) summary
    pfam02485
    Location:136 → 373
    Branch; Core-2/I-Branching enzyme
Nucleotide Protein
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