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mlt-2 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172459, updated on 2-Nov-2024

Summary

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Official Symbol
mlt-2
Official Full Name
ANK_REP_REGION domain-containing protein
Primary source
WormBase:WBGene00007252
Locus tag
CELE_C01H6.2
See related
AllianceGenome:WB:WBGene00007252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cilium. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mlt-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (7204541..7207717, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Flavin-containing monooxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. Lažetić V, et al. Genetics, 2017 Jan. PMID 27799278, Free PMC Article
  2. Titanium Dioxide (TiO(2)) Nanoparticle Toxicity in a Caenorhabditis elegans Model. Huang ST, et al. Toxics, 2023 Dec 5. PMID 38133390, Free PMC Article
  3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in ecdysis, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to ciliary inversin compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ANK_REP_REGION domain-containing protein
NP_492036.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7204541..7207717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059635.4 → NP_492036.2  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492036.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17583
    Conserved Domains (4) summary
    PHA02876
    Location:9 → 214
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:201 → 351
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:51 → 79
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:53 → 135
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version

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