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nhr-23 Nuclear hormone receptor family member nhr-23 [ Caenorhabditis elegans ]

Gene ID: 172460, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-23
Official Full Name
Nuclear hormone receptor family member nhr-23
Primary source
WormBase:WBGene00003622
Locus tag
CELE_C01H6.5
See related
AllianceGenome:WB:WBGene00003622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in chromatin and nucleus. Is expressed in several structures, including gonad; hypodermis; oocyte; spermatocyte; and vulva. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Orthologous to human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-23 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (7214745..7221299)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Flavin-containing monooxygenase Neighboring gene Metal transporter cnnm-4 Neighboring gene Bromo domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An nhr-23::mScarlet::3xMyc knock-in allele for studying spermatogenesis and molting. Myles KM, et al. MicroPubl Biol, 2023. PMID 37854098, Free PMC Article
  2. NHR-23 dependent collagen and hedgehog-related genes required for molting. Kouns NA, et al. Biochem Biophys Res Commun, 2011 Oct 7. PMID 21910973, Free PMC Article
  3. An nhr-85::GFP::AID*::3xFLAG knock-in allele for investigation of molting and oscillatory gene regulation. Myles KM, et al. MicroPubl Biol, 2023. PMID 37927911, Free PMC Article
  4. A spontaneous TIR1 loss-of-function allele in C. elegans. Myles KM, et al. MicroPubl Biol, 2023. PMID 37908494, Free PMC Article
  5. Supplementary nuclear receptor NHR-60 is required for normal embryonic and early larval development of Caenorhabditis elegans. Simecková K, et al. Folia Biol (Praha), 2007. PMID 17579999

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
    Title: Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
  2. NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
    Title: NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
  3. The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
    Title: The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
  4. these results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa.
    Title: NHR-23 dependent collagen and hedgehog-related genes required for molting.
  5. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting.
    Title: The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-23
NP_001020975.1
  • Confirmed by transcript evidence
NP_001020977.1
  • Confirmed by transcript evidence
NP_001032969.1
  • Confirmed by transcript evidence
NP_001032971.1
  • Confirmed by transcript evidence
NP_001367012.1
  • Confirmed by transcript evidence
NP_001379448.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7214745..7221299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025806.7 → NP_001020977.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001020977.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41828
    Conserved Domains (2) summary
    cd06968
    Location:5 → 99
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    cl11397
    Location:233 → 429
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. NM_001037880.6 → NP_001032969.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001032969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41828
    Conserved Domains (2) summary
    cd06968
    Location:5 → 99
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    cl11397
    Location:235 → 431
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  3. NM_001025804.6 → NP_001020975.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001020975.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41828, Q17380, Q17584, Q3S1J2, Q3S1J3, Q3S1J4, Q5FC60, Q9BJL3
    Conserved Domains (2) summary
    cd06968
    Location:156 → 250
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    cl11397
    Location:384 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. NM_001380645.2 → NP_001367012.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd06968
    Location:121 → 215
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    cl11397
    Location:349 → 545
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  5. NM_001037882.6 → NP_001032971.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001032971.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41828
    Conserved Domains (2) summary
    cd06968
    Location:121 → 215
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    cl11397
    Location:351 → 547
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  6. NM_001392520.1 → NP_001379448.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cl02596
    Location:1 → 23
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:157 → 353
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41828.2

Gene LinkOut

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