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lars-2 leucine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 172499, updated on 2-Nov-2024

Summary

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Official Symbol
lars-2
Official Full Name
leucine--tRNA ligase
Primary source
WormBase:WBGene00003074
Locus tag
CELE_ZK524.3
See related
AllianceGenome:WB:WBGene00003074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in body wall musculature; intestine; and neurons. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lars-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7457152..7460756, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phorbol ester/diacylglycerol-binding protein unc-13;Protein kinase C Neighboring gene Presenilin spe-4 Neighboring gene Protein kinase domain-containing protein Neighboring gene SERTA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome. Pierce SB, et al. Am J Hum Genet, 2013 Apr 4. PMID 23541342, Free PMC Article
  2. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Lee SS, et al. Nat Genet, 2003 Jan. PMID 12447374
  3. Mitochondrial genetics. Lemire B. WormBook, 2005 Sep 14. PMID 18023115, Free PMC Article
  4. Ageing and oxidants in the nematode Caenorhabditis elegans. Gems D. SEB Exp Biol Ser, 2009. PMID 19418991
  5. A systematic RNAi screen for longevity genes in C. elegans. Hamilton B, et al. Genes Dev, 2005 Jul 1. PMID 15998808, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine--tRNA ligase
NP_001021875.1
  • Confirmed by transcript evidence
NP_001129803.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7457152..7460756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026704.6 → NP_001021875.1  leucine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBH2, Q23511
    Conserved Domains (1) summary
    TIGR00396
    Location:29 → 747
    leuS_bact; leucyl-tRNA synthetase, eubacterial and mitochondrial family

  2. NM_001136331.4 → NP_001129803.1  leucine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129803.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3WFV4
    Conserved Domains (1) summary
    TIGR00396
    Location:1 → 343
    leuS_bact; leucyl-tRNA synthetase, eubacterial and mitochondrial family
Nucleotide Protein
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