pbrm-1 Bromo domain-containing protein;HMG box domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pbrm-1
Official Full Name: Bromo domain-containing protein;HMG box domain-containing protein
Primary source: WormBase:WBGene00007042
Locus tag: CELE_C26C6.1
See related: AllianceGenome:WB:WBGene00007042
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity. Involved in gonad development. Predicted to be located in nucleus. Predicted to be part of RSC-type complex and SWI/SNF complex. Is expressed in several structures, including enteric muscle; hypodermis; nervous system; pharynx; and somatic cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pbrm-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (7495437..7503582)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans.
Title: PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C26C6.1 (e-PCR)
- UniSTS:306043

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RSC-type complex	IEA Inferred from Electronic Annotation more info
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bromo domain-containing protein;HMG box domain-containing protein

NP_001021008.1

Confirmed by transcript evidence

NP_001379442.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7495437..7503582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025837.4 → NP_001021008.1 Bromo domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021008.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEY5

Conserved Domains (7) summary

cd05515
Location:710 → 815

Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05520
Location:343 → 443

Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05524
Location:40 → 153

Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05526
Location:822 → 936

Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd00084
Location:1451 → 1503

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd04717
Location:993 → 1114

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cl02556
Location:198 → 293

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001392571.1 → NP_001379442.1 HMG box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q565A2

Conserved Domains (2) summary

cd00084
Location:77 → 133

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

pfam17017
Location:161 → 238

zf-C2H2_aberr; Aberrant zinc-finger