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dcp-66 Transcription factor dcp-66 [ Caenorhabditis elegans ]

Gene ID: 172507, updated on 2-Nov-2024

Summary

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Official Symbol
dcp-66
Official Full Name
Transcription factor dcp-66
Primary source
WormBase:WBGene00000938
Locus tag
CELE_C26C6.5
See related
AllianceGenome:WB:WBGene00000938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in chromatin organization; mitochondrial unfolded protein response; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in body wall musculature; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to several human genes including GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dcp-66 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7536104..7542159, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein G(o) subunit alpha Neighboring gene Zinc metalloproteinase nas-36 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene ncRNA Neighboring gene DUF4604 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Divergent regulatory roles of NuRD chromatin remodeling complex subunits GATAD2 and CHD4 in Caenorhabditis elegans. Golden NL, et al. Genetics, 2022 May 5. PMID 35323946, Free PMC Article
  2. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
  3. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
  4. Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo. Kagias K, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493276, Free PMC Article
  5. SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans. Konwar C, et al. Sci Rep, 2022 Jun 22. PMID 35732652, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of cis-elements from pgp-12 and DCP-66 show that distinct regulatory elements are able to mediate similar expression patterns
    Title: Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Transcription factor dcp-66
NP_492111.3
  • Confirmed by transcript evidence
NP_871831.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7536104..7542159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182031.6 → NP_871831.3  Transcription factor dcp-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871831.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECM2, G5ED89

  2. NM_059710.8 → NP_492111.3  Transcription factor dcp-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492111.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECM2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ED89.2

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