mce-1 VOC domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mce-1
Official Full Name: VOC domain-containing protein
Primary source: WormBase:WBGene00008415
Locus tag: CELE_D2030.5
See related: AllianceGenome:WB:WBGene00008415
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable methylmalonyl-CoA epimerase activity. Predicted to be involved in L-methylmalonyl-CoA metabolic process. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Used to study methylmalonic acidemia. Orthologous to human MCEE (methylmalonyl-CoA epimerase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mce-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (7582106..7583333)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the protein expression pattern revealed expression in the pharynx, hypodermis and, most prominently in body wall muscles.
Title: Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2030.5 (e-PCR)
- UniSTS:316481

STS1-116 (e-PCR)
- UniSTS:241601

D2030.4 (e-PCR)
- UniSTS:320493

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylmalonyl-CoA epimerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-methylmalonyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: VOC domain-containing protein

NP_492120.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7582106..7583333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059719.6 → NP_492120.1 VOC domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492120.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEG4

Conserved Domains (1) summary

TIGR03081
Location:34 → 161

metmalonyl_epim; methylmalonyl-CoA epimerase