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lsy-22 STI1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172536, updated on 2-Nov-2024

Summary

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Official Symbol
lsy-22
Official Full Name
STI1 domain-containing protein
Primary source
WormBase:WBGene00009188
Locus tag
CELE_F27D4.2
See related
AllianceGenome:WB:WBGene00009188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor binding activity. Is expressed in several structures, including body wall musculature and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lsy-22 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (7704564..7718516, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein Neighboring gene putative electron transfer flavoprotein subunit alpha, mitochondrial Neighboring gene Photosystem II protein I Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans. Flowers EB, et al. Development, 2010 Jun. PMID 20431118, Free PMC Article
  2. Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans. Medwig-Kinney TN, et al. Elife, 2023 Dec 1. PMID 38038410, Free PMC Article
  3. Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Zhao G, et al. Genome Res, 2007 Mar. PMID 17284674, Free PMC Article
  4. The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. Uehara T, et al. PLoS Genet, 2015 Jan. PMID 25569233, Free PMC Article
  5. Analysis of multiple ethyl methanesulfonate-mutagenized Caenorhabditis elegans strains by whole-genome sequencing. Sarin S, et al. Genetics, 2010 Jun. PMID 20439776, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Besides their phenotypic similarities, unc-37 and lsy-22 show genetic interactions and UNC-37 and LSY-22 proteins also physically bind to each other in vivo.
    Title: The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
STI1 domain-containing protein
NP_001379174.1
  • Partially confirmed by transcript evidence
NP_492147.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7704564..7718516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059746.6 → NP_492147.2  STI1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492147.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPI4

  2. NM_001392596.1 → NP_001379174.1  STI1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93616
    Conserved Domains (1) summary
    NF035934
    Location:2 → 32
    ESAT6_2; pore-forming ESAT-6 family protein
Nucleotide Protein
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