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apb-3 AP-3 complex subunit beta [ Caenorhabditis elegans ]

Gene ID: 172553, updated on 2-Nov-2024

Summary

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Official Symbol
apb-3
Official Full Name
AP-3 complex subunit beta
Primary source
WormBase:WBGene00000163
Locus tag
CELE_R11A5.1
See related
AllianceGenome:WB:WBGene00000163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryo development and lysosome organization. Predicted to be located in axon cytoplasm and clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome (multiple); developmental and epileptic encephalopathy 48; interstitial lung disease (multiple); and neutropenia. Orthologous to several human genes including AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apb-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (7853750..7857853)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 60;histone acetyltransferase Neighboring gene MATH domain-containing protein Neighboring gene Transcription initiation factor TFIID subunit 5 Neighboring gene Protein nud-2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. Harrington AJ, et al. J Neurosci, 2012 Feb 8. PMID 22323726, Free PMC Article
  2. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
  3. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article
  4. LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α. Nadiminti SSP, et al. PLoS Genet, 2024 May. PMID 38722918, Free PMC Article
  5. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. Holmes A, et al. J Cell Sci, 2007 Aug 1. PMID 17636000

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-3 complex subunit beta
NP_492170.2
  • Confirmed by transcript evidence
NP_492171.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7853750..7857853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059769.6 → NP_492170.2  AP-3 complex subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492170.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45718
    Conserved Domains (4) summary
    cl22853
    Location:35 → 84
    Motor_domain; Myosin and Kinesin motor domain
    pfam01602
    Location:23 → 546
    Adaptin_N; Adaptin N terminal region
    pfam14796
    Location:740 → 826
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    sd00044
    Location:100 → 128
    HEAT; HEAT repeat [structural motif]

  2. NM_059770.6 → NP_492171.2  AP-3 complex subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492171.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62348
    Conserved Domains (4) summary
    cl22853
    Location:35 → 84
    Motor_domain; Myosin and Kinesin motor domain
    pfam01602
    Location:23 → 536
    Adaptin_N; Adaptin N terminal region
    pfam14796
    Location:730 → 816
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    sd00044
    Location:100 → 128
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
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