pck-2 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pck-2
Official Full Name: phosphoenolpyruvate carboxykinase (GTP)
Primary source: WormBase:WBGene00011232
Locus tag: CELE_R11A5.4
See related: AllianceGenome:WB:WBGene00011232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to dexamethasone stimulus; and gluconeogenesis. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including body wall musculature; intestine; muscle cell; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to several human genes including PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pck-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (7866136..7872100)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.
Title: Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R11A5.5 (e-PCR)
- UniSTS:305949

R11A5.6 (e-PCR)
- UniSTS:316988

R11A5.4 (e-PCR)
- UniSTS:307872

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase activity	IEA Inferred from Electronic Annotation more info
enables purine nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glycerol biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in propionate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: phosphoenolpyruvate carboxykinase (GTP)

NP_001366912.1

Confirmed by transcript evidence

NP_001367090.1

Confirmed by transcript evidence

NP_001367091.1

Confirmed by transcript evidence

NP_001379420.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7866136..7872100

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380767.3 → NP_001366912.1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O02286

Conserved Domains (1) summary

cd00819
Location:57 → 647

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
NM_001380768.1 → NP_001367091.1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JKI2

Conserved Domains (1) summary

cd00819
Location:21 → 611

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
NM_001392619.1 → NP_001379420.1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JKI1

Conserved Domains (1) summary

cd00819
Location:32 → 622

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
NM_001380772.1 → NP_001367090.1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JKI3

Conserved Domains (1) summary

cd00819
Location:1 → 580

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...