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H05L14.2 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172577, updated on 2-Nov-2024

Summary

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Official Symbol
H05L14.2
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00010367
Locus tag
CELE_H05L14.2
See related
AllianceGenome:WB:WBGene00010367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in gonad. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See H05L14.2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (7984889..7993161)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
  2. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_001337282.1
  • Confirmed by transcript evidence
NP_001360419.1
  • Confirmed by transcript evidence
NP_001368637.1
  • Confirmed by transcript evidence
NP_001368638.1
  • Confirmed by transcript evidence
NP_492199.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7984889..7993161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373131.2 → NP_001360419.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUJ8
    Conserved Domains (5) summary
    TIGR02169
    Location:1181 → 1374
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam06003
    Location:337 → 472
    SMN; Survival motor neuron protein (SMN)
    cd00162
    Location:1553 → 1594
    RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
    pfam09770
    Location:408 → 530
    PAT1; Topoisomerase II-associated protein PAT1
    pfam13639
    Location:1553 → 1594
    zf-RING_2; Ring finger domain

  2. NM_059798.7 → NP_492199.4  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUI7
    Conserved Domains (5) summary
    TIGR02169
    Location:1285 → 1390
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam06003
    Location:351 → 486
    SMN; Survival motor neuron protein (SMN)
    cd00162
    Location:1569 → 1610
    RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
    pfam09770
    Location:422 → 544
    PAT1; Topoisomerase II-associated protein PAT1
    pfam13639
    Location:1569 → 1610
    zf-RING_2; Ring finger domain

  3. NM_001380787.1 → NP_001368637.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUG1
    Conserved Domains (3) summary
    PHA03378
    Location:389 → 530
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:1198 → 1389
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13639
    Location:1567 → 1608
    zf-RING_2; Ring finger domain

  4. NM_001380788.1 → NP_001368638.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUY1
    Conserved Domains (2) summary
    PHA03378
    Location:389 → 530
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:1198 → 1389
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. NM_001350372.5 → NP_001337282.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUI4
    Conserved Domains (6) summary
    TIGR02169
    Location:1052 → 1245
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam06003
    Location:208 → 343
    SMN; Survival motor neuron protein (SMN)
    cd00162
    Location:1424 → 1465
    RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
    pfam07964
    Location:408 → 632
    Red1; Rec10 / Red1
    pfam09770
    Location:279 → 401
    PAT1; Topoisomerase II-associated protein PAT1
    pfam13639
    Location:1424 → 1465
    zf-RING_2; Ring finger domain
Nucleotide Protein
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