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aho-3 Alpha/beta hydrolase domain-containing protein aho-3 [ Caenorhabditis elegans ]

Gene ID: 172585, updated on 2-Nov-2024

Summary

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Official Symbol
aho-3
Official Full Name
Alpha/beta hydrolase domain-containing protein aho-3
Primary source
WormBase:WBGene00045192
Locus tag
CELE_K04G2.2
See related
AllianceGenome:WB:WBGene00045192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in associative learning and behavioral response to starvation. Located in cytoplasmic vesicle and sensory dendrite. Is expressed in several structures, including AIY; amphid neurons; pharyngeal muscle cell; serotonergic neurons; and spermatheca. Orthologous to several human genes including ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aho-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (8030959..8032880)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 2 subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATPase family protein 2 homolog Neighboring gene SHSP domain-containing protein Neighboring gene palmitoyl-protein hydrolase Neighboring gene Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans. Nishio N, et al. Genes Cells, 2012 May. PMID 22512337, Free PMC Article
  2. Genetic control of temperature preference in the nematode Caenorhabditis elegans. Mohri A, et al. Genetics, 2005 Mar. PMID 15654086, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Alpha/beta hydrolase domain-containing protein aho-3
NP_492210.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8030959..8032880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059809.8 → NP_492210.2  Alpha/beta hydrolase domain-containing protein aho-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492210.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21221
    Conserved Domains (1) summary
    COG1073
    Location:114 → 302
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21221.2

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