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ins-18 INSulin related [ Caenorhabditis elegans ]

Gene ID: 172600, updated on 2-Nov-2024

Summary

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Official Symbol
ins-18
Official Full Name
INSulin related
Primary source
WormBase:WBGene00002101
Locus tag
CELE_T28B8.2
See related
AllianceGenome:WB:WBGene00002101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Is expressed in several structures, including coelomocyte; gonad; head muscle; neurons; and somatic nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ins-18 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (8147427..8149651)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Amiloride-sensitive sodium channel Neighboring gene Secreted protein Neighboring gene DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide. Kawano T, et al. Biosci Biotechnol Biochem, 2003 Dec. PMID 14730154
  2. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Kawano T, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873623
  3. Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans. Matsunaga Y, et al. Biosci Biotechnol Biochem, 2018 Jan. PMID 29303423
  4. Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans. Ryu L, et al. EMBO J, 2018 Aug 1. PMID 29925517, Free PMC Article
  5. Identification and analysis of insulin like peptides in nematode secretomes provide targets for parasite control. Gahoi S, et al. Bioinformation, 2016. PMID 28356679, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggests that INS-18 is a DAF-2 antagonist that functions mainly in nerve cells.
    Title: Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in maintenance of dauer IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
INSulin related
NP_001379200.1
  • Product from WormBase gene class ins;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8147427..8149651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392642.1 → NP_001379200.1  INSulin related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECC6
Nucleotide Protein
Heading Accession and Version

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