rsd-6 Tudor domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rsd-6
Official Full Name: Tudor domain-containing protein
Primary source: WormBase:WBGene00004684
Locus tag: CELE_F16D3.2
See related: AllianceGenome:WB:WBGene00004684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in P granule organization; piRNA processing; and spermatogenesis. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rsd-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (8358254..8363858, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This genetic screen also identified rsd-6, a gene that maintains genome integrity under unfavorable conditions, as a key regulator of worm antiviral silencing, demonstrating an interplay between antiviral immunity and genome integrity maintenance.
Title: Transgene-Assisted Genetic Screen Identifies rsd-6 and Novel Genes as Key Components of Antiviral RNA Interference in Caenorhabditis elegans.
RSD-2 and RSD-6 promote germ cell immortality at stressful temperatures by maintaining transgenerational epigenetic inheritance of endogenous siRNA populations that promote genome silencing.
Title: Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.
The ultimate functions of rsd-2 and rsd-6 in systemic RNA interference are remarkably complex and environmentally responsive.
Title: The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F16D3.2 (e-PCR)
- UniSTS:307497

STS1-139 (e-PCR)
- UniSTS:241625

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in P granule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tudor domain-containing protein

NP_492269.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8358254..8363858 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059868.10 → NP_492269.2 Tudor domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492269.2

Status: REVIEWED

UniProtKB/TrEMBL

Q19491, Q19492

Conserved Domains (2) summary

PHA03307
Location:82 → 319

PHA03307; transcriptional regulator ICP4; Provisional

pfam00567
Location:520 → 626

TUDOR; Tudor domain