ngp-1 Nucleolar GTP-binding protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ngp-1
Official Full Name: Nucleolar GTP-binding protein 2
Primary source: WormBase:WBGene00003596
Locus tag: CELE_T19A6.2
See related: AllianceGenome:WB:WBGene00003596
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in intestine; nervous system; and pharynx. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ngp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (8394726..8398626)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ngp-1 gene is required for nonsense-mediated mRNA decay pathway and proper development in C. elegans.
Title: Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T19A6.2 (e-PCR)
- UniSTS:317531

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nucleolar GTP-binding protein 2

NP_001379024.1

Confirmed by transcript evidence

NP_492275.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8394726..8398626

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392677.1 → NP_001379024.1 Nucleolar GTP-binding protein 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U365

Conserved Domains (3) summary

cd01858
Location:165 → 321

NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases

pfam08153
Location:1 → 131

NGP1NT; NGP1NT (NUC091) domain

cl38936
Location:270 → 402

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_059874.6 → NP_492275.2 Nucleolar GTP-binding protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492275.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9XXN4

Conserved Domains (4) summary

cd01858
Location:224 → 380

NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases

COG1161
Location:204 → 491

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

pfam08153
Location:61 → 190

NGP1NT; NGP1NT (NUC091) domain

cl21455
Location:329 → 461

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases