ceh-6 Homeobox protein ceh-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-6
Official Full Name: Homeobox protein ceh-6
Primary source: WormBase:WBGene00000431
Locus tag: CELE_K02B12.1
See related: AllianceGenome:WB:WBGene00000431
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in transdifferentiation. Acts upstream of with a positive effect on multicellular organismal-level water homeostasis. Located in cytosol and nucleus. Is expressed in several structures, including P1.a; P10.a; excretory cell; neurons; and rectal epithelial cell. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to several human genes including POU3F1 (POU class 3 homeobox 1); POU3F3 (POU class 3 homeobox 3); and POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ceh-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (8498112..8502604, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings support the idea that CEH-6 is required for the expression of a set of transport and channel genes in the C. elegans excretory cell.
Title: Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6.
AQP-8 is a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6
Title: Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02B12.1 (e-PCR)
- UniSTS:314583

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein ceh-6

NP_492304.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8498112..8502604 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059903.6 → NP_492304.1 Homeobox protein ceh-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20268, Q9GSZ8

Conserved Domains (2) summary

smart00352
Location:188 → 261

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:284 → 337

Homeobox; Homeobox domain