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mfap-1 Microfibrillar-associated protein 1 [ Caenorhabditis elegans ]

Gene ID: 172661, updated on 2-Nov-2024

Summary

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Official Symbol
mfap-1
Official Full Name
Microfibrillar-associated protein 1
Primary source
WormBase:WBGene00009671
Locus tag
CELE_F43G9.10
See related
AllianceGenome:WB:WBGene00009671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in body wall musculature; intestine; pharynx; and vulval muscle. Orthologous to human MFAP1 (microfibril associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mfap-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (8638514..8640236, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene GCF C-terminal domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. Ma L, et al. PLoS Genet, 2012. PMID 22829783, Free PMC Article
  2. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
  3. The extracellular matrix phenome across species. Statzer C, et al. Matrix Biol Plus, 2020 Nov. PMID 33543035, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our studies indicate that C. elegans mfap-1 encodes a splicing factor that can affect alternative splicing
    Title: The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Microfibrillar-associated protein 1
NP_492340.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8638514..8640236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059939.9 → NP_492340.1  Microfibrillar-associated protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492340.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93712
    Conserved Domains (1) summary
    pfam06991
    Location:220 → 427
    MFAP1; Microfibril-associated/Pre-mRNA processing
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93712.1

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