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Meis1 Meis homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 17268, updated on 28-Oct-2024

Summary

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Official Symbol
Meis1provided by MGI
Official Full Name
Meis homeobox 1provided by MGI
Primary source
MGI:MGI:104717
See related
Ensembl:ENSMUSG00000020160 AllianceGenome:MGI:104717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Evi8; C530044H18Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study restless legs syndrome. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in bladder adult (RPKM 25.6), CNS E11.5 (RPKM 9.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Meis1 in Genome Data Viewer
Location:
11 A3.1; 11 11.11 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (18830428..18968992, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (18880428..19019651, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31674 Neighboring gene predicted gene, 23021 Neighboring gene RIKEN cDNA 8430419K02 gene Neighboring gene STARR-seq mESC enhancer starr_28733 Neighboring gene STARR-seq mESC enhancer starr_28735 Neighboring gene STARR-seq mESC enhancer starr_28736 Neighboring gene predicted gene 16141 Neighboring gene RIKEN cDNA 4933406G16 gene Neighboring gene STARR-seq mESC enhancer starr_28738 Neighboring gene STARR-seq mESC enhancer starr_28739 Neighboring gene STARR-seq mESC enhancer starr_28740 Neighboring gene predicted gene, 53669

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Meis1: effects on motor phenotypes and the sensorimotor system in mice. Salminen AV, et al. Dis Model Mech, 2017 Aug 1. PMID 28645892, Free PMC Article
  2. Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Cai M, et al. Blood, 2012 Jul 12. PMID 22665933, Free PMC Article
  3. Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum. Isogai E, et al. Biomed Res, 2022. PMID 35718449
  4. Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice. Liu Y, et al. J Adv Res, 2022 Jul. PMID 35777912, Free PMC Article
  5. Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome. Cathiard L, et al. J Sleep Res, 2021 Oct. PMID 34008292

See all (249) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
    Title: A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
  2. Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
    Title: Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
  3. A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
    Title: A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
  4. Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
    Title: Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
  5. Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
    Title: Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
  6. Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
    Title: Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
  7. Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
    Title: Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
  8. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
    Title: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
  9. Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
    Title: Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
  10. Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.
    Title: Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.
Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeobox protein Meis1
Names
myeloid ecotropic viral integration site 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193271.1 → NP_001180200.1  homeobox protein Meis1 isoform B

    See identical proteins and their annotated locations for NP_001180200.1

    Status: VALIDATED

    Description
    Transcript Variant: : This variant (B) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK140748, AL645570
    Consensus CDS
    CCDS56760.1
    UniProtKB/Swiss-Prot
    B1ARH5, Q5SVC8, Q60954, Q60955, Q8CIL0
    UniProtKB/TrEMBL
    H3BLB6
    Related
    ENSMUSP00000069277.8, ENSMUST00000068264.14
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. NM_010789.3 → NP_034919.1  homeobox protein Meis1 isoform A

    See identical proteins and their annotated locations for NP_034919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A).
    Source sequence(s)
    AL603984, AL645570
    Consensus CDS
    CCDS24453.1
    UniProtKB/TrEMBL
    H3BLB6
    Related
    ENSMUSP00000139219.2, ENSMUST00000185131.8
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 191
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    18830428..18968992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314312.3 → XP_017169801.1  homeobox protein Meis1 isoform X2

    UniProtKB/TrEMBL
    H3BLB6
    Conserved Domains (2) summary
    pfam05920
    Location:241 → 280
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 161
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_006514559.5 → XP_006514622.1  homeobox protein Meis1 isoform X1

    Conserved Domains (3) summary
    TIGR01628
    Location:277 → 408
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05920
    Location:241 → 280
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 161
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_030245628.2 → XP_030101488.1  homeobox protein Meis1 isoform X3

    UniProtKB/TrEMBL
    Q3UJ00
    Related
    ENSMUST00000118661.8
    Conserved Domains (2) summary
    pfam05920
    Location:146 → 185
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:1 → 48
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RNA

  1. XR_003949337.2 RNA Sequence

  2. XR_001779899.3 RNA Sequence

  3. XR_001779900.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60954.1 GenPept UniProtKB/Swiss-Prot:Q60954

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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