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F55H12.3 CUB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172702, updated on 2-Nov-2024

Summary

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Official Symbol
F55H12.3
Official Full Name
CUB domain-containing protein
Primary source
WormBase:WBGene00010134
Locus tag
CELE_F55H12.3
See related
AllianceGenome:WB:WBGene00010134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Notch binding activity. Predicted to be located in extracellular region and membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F55H12.3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
52
Sequence:
Chromosome: I; NC_003279.8 (8876319..8893317)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Transporter Neighboring gene DB domain-containing protein Neighboring gene Acetylcholine receptor subunit beta-type unc-29 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Tian X, et al. Development, 2004 Dec. PMID 15539484
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUB domain-containing protein
NP_492397.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8876319..8893317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059996.7 → NP_492397.4  CUB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492397.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90891
    Conserved Domains (9) summary
    cd00033
    Location:1066 → 1110
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:604 → 651
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00179
    Location:851 → 884
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:185 → 217
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00185
    Location:2530 → 2590
    TNFRSF; CRD2 [structural motif]
    pfam02494
    Location:2235 → 2315
    HYR; HYR domain
    pfam07699
    Location:2517 → 2567
    GCC2_GCC3; GCC2 and GCC3
    pfam07974
    Location:1869 → 1900
    EGF_2; EGF-like domain
    cl22855
    Location:2510 → 2657
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein
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