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madd-4 Protein madd-4 [ Caenorhabditis elegans ]

Gene ID: 172706, updated on 2-Nov-2024

Summary

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Official Symbol
madd-4
Official Full Name
Protein madd-4
Primary source
WormBase:WBGene00009958
Locus tag
CELE_F53B6.2
See related
AllianceGenome:WB:WBGene00009958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables signaling receptor binding activity. Involved in dorsal/ventral axon guidance and synapse organization. Located in extracellular space. Is expressed in blast cell; coelomocyte; and nervous system. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); ADAMTSL1 (ADAMTS like 1); and ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See madd-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
18
Sequence:
Chromosome: I; NC_003279.8 (8931033..8942292, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Tetraspanin-15 Neighboring gene Fungus-Induced Protein Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains. Pinan-Lucarré B, et al. Nature, 2014 Jul 24. PMID 24896188
  2. The HSPG syndecan is a core organizer of cholinergic synapses. Zhou X, et al. J Cell Biol, 2021 Sep 6. PMID 34213535, Free PMC Article
  3. The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1. Platsaki S, et al. J Biol Chem, 2020 Nov 27. PMID 32928959, Free PMC Article
  4. Extracellular Matrix Muscle Arm Development Defective Protein Cooperates with the One Immunoglobulin Domain Protein To Suppress Precocious Synaptic Remodeling. Chen C, et al. ACS Chem Neurosci, 2021 Jun 2. PMID 34019371
  5. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Maro GS, et al. Neuron, 2015 Jun 17. PMID 26028574, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions.
    Title: Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions.
  2. The HSPG syndecan is a core organizer of cholinergic synapses.
    Title: The HSPG syndecan is a core organizer of cholinergic synapses.
  3. Extracellular Matrix Muscle Arm Development Defective Protein Cooperates with the One Immunoglobulin Domain Protein To Suppress Precocious Synaptic Remodeling.
    Title: Extracellular Matrix Muscle Arm Development Defective Protein Cooperates with the One Immunoglobulin Domain Protein To Suppress Precocious Synaptic Remodeling.
  4. The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1.
    Title: The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1.
  5. we demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions
    Title: EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
  6. This study demonstrated that C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment
    Title: C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.
  7. previously uncharacterized protein called MADD-4 is secreted by the dorsal and ventral nerve cords of the nematode C. elegans to attract sensory axons and muscle membrane extensions called muscle arms
    Title: MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.
  8. Punctin/madd-4, the C. elegans orthologue of mammalian punctin-1 and punctin-2, encodes neurally secreted isoforms that specify the excitatory or inhibitory identity of postsynaptic neuromuscular junction domains
    Title: C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein madd-4
NP_001250933.1
  • Confirmed by transcript evidence
NP_492405.3
  • Confirmed by transcript evidence
NP_871884.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8931033..8942292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060004.5 → NP_492405.3  Protein madd-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492405.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    I2HA89, P90884, Q8I4I1
    Conserved Domains (2) summary
    smart00408
    Location:666 → 723
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:26 → 71
    TSP1; Thrombospondin type 1 repeats

  2. NM_182084.9 → NP_871884.1  Protein madd-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871884.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90884
    Conserved Domains (3) summary
    smart00408
    Location:332 → 389
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:48 → 104
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:333 → 388
    IG_like; Immunoglobulin like

  3. NM_001264004.5 → NP_001250933.1  Protein madd-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001250933.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90884
    Conserved Domains (3) summary
    smart00408
    Location:664 → 721
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:26 → 71
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:665 → 720
    IG_like; Immunoglobulin like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90884.5

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