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spd-2 Spindle-defective protein 2 [ Caenorhabditis elegans ]

Gene ID: 172712, updated on 18-Sep-2024

Summary

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Official Symbol
spd-2
Official Full Name
Spindle-defective protein 2
Primary source
WormBase:WBGene00004953
Locus tag
CELE_F32H2.3
See related
AllianceGenome:WB:WBGene00004953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Is expressed in germ line; gonad; and intestinal cell. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See spd-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (8966985..8970081, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene snRNA-activating protein complex subunit 4 homolog Neighboring gene Mediator of RNA polymerase II transcription subunit 31 Neighboring gene Integrator complex subunit 1 R4 domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene SRCR domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulated changes in material properties underlie centrosome disassembly during mitotic exit. Mittasch M, et al. J Cell Biol, 2020 Apr 6. PMID 32050025, Free PMC Article
  2. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation. Sugioka K, et al. Elife, 2017 Jan 16. PMID 28092264, Free PMC Article
  3. SPD-2/CEP192 and CDK Are Limiting for Microtubule-Organizing Center Function at the Centrosome. Yang R, et al. Curr Biol, 2015 Jul 20. PMID 26119750
  4. Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans. Lu Y, et al. PLoS One, 2014. PMID 25360893, Free PMC Article
  5. Polo-like kinase 4 shapes up. Levine MS, et al. Structure, 2014 Aug 5. PMID 25099950

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome-templated microtubule nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
  
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Spindle-defective protein 2
NP_492414.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8966985..8970081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060013.8 → NP_492414.1  Spindle-defective protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91870
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91870.1

Gene LinkOut

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