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gei-17 E3 SUMO-protein ligase gei-17 [ Caenorhabditis elegans ]

Gene ID: 172733, updated on 2-Nov-2024

Summary

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Official Symbol
gei-17
Official Full Name
E3 SUMO-protein ligase gei-17
Primary source
WormBase:WBGene00001574
Locus tag
CELE_W10D5.3
See related
AllianceGenome:WB:WBGene00001574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in chromatin and metaphase plate. Is expressed in motor neurons. Orthologous to several human genes including PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gei-17 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (9100845..9107848, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MEF2 transcription factor homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Neighboring gene Poly(A) RNA polymerase gld-4 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans. Eki T, et al. DNA Res, 2007 Aug 31. PMID 17921522, Free PMC Article
  2. Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development. Fergin A, et al. PLoS Genet, 2022 Jun. PMID 35666766, Free PMC Article
  3. A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis. Pelisch F, et al. Mol Cell, 2017 Jan 5. PMID 27939944, Free PMC Article
  4. Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans. Davis-Roca AC, et al. PLoS Genet, 2018 Sep. PMID 30180169, Free PMC Article
  5. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic metaphase I homologous chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of mitotic DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of error-prone translesion synthesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of error-prone translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in metaphase plate IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 SUMO-protein ligase gei-17
NP_001021677.3
  • Confirmed by transcript evidence
NP_001021678.3
  • Partially confirmed by transcript evidence
NP_001021679.3
  • Partially confirmed by transcript evidence
NP_492442.3
  • Confirmed by transcript evidence
NP_492443.3
  • Confirmed by transcript evidence
NP_492444.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9100845..9107848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026506.5 → NP_001021677.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021677.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94361
    Conserved Domains (2) summary
    pfam02891
    Location:356 → 405
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:164 → 302
    PINIT; PINIT domain

  2. NM_060043.5 → NP_492444.4  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492444.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q564X2, Q7Z0X3, Q7Z0X4, Q94361, Q94363, Q9U326
    Conserved Domains (3) summary
    pfam02891
    Location:411 → 460
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam10599
    Location:628 → 724
    Nup_retrotrp_bd; Retro-transposon transporting motif
    pfam14324
    Location:219 → 357
    PINIT; PINIT domain

  3. NM_060041.7 → NP_492442.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492442.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94361
    Conserved Domains (2) summary
    pfam02891
    Location:356 → 405
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:164 → 302
    PINIT; PINIT domain

  4. NM_060042.5 → NP_492443.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492443.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94361
    Conserved Domains (2) summary
    pfam02891
    Location:354 → 403
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:162 → 300
    PINIT; PINIT domain

  5. NM_001026507.5 → NP_001021678.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021678.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94361
    Conserved Domains (3) summary
    pfam02891
    Location:356 → 405
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam10599
    Location:573 → 669
    Nup_retrotrp_bd; Retro-transposon transporting motif
    pfam14324
    Location:164 → 302
    PINIT; PINIT domain

  6. NM_001026508.7 → NP_001021679.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021679.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94361
    Conserved Domains (3) summary
    pfam02891
    Location:289 → 338
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam10599
    Location:506 → 601
    Nup_retrotrp_bd; Retro-transposon transporting motif
    pfam14324
    Location:97 → 235
    PINIT; PINIT domain

RNA

  1. NR_000051.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94361.4

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