gld-4 Poly(A) RNA polymerase gld-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gld-4
Official Full Name: Poly(A) RNA polymerase gld-4
Primary source: WormBase:WBGene00014115
Locus tag: CELE_ZK858.1
See related: AllianceGenome:WB:WBGene00014115
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables poly(A) RNA polymerase activity. Involved in cytosolic mRNA polyadenylation and positive regulation of meiotic cell cycle. Located in P granule. Is expressed in Z2; Z3; and germ line. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A) and TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gld-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (9118115..9123181)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A reduced number of polysomes are detected in gld-4 mutants and GLD-4 protein co-sediments with polysomes, which together suggest that GLD-4 might stimulate or maintain translation directly.
Title: The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms.
GLD-4 is predominantly expressed in germ cells, and its activity is essential for early meiotic progression of male and female gametes in the absence of GLD-2
Title: Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK858.1 (e-PCR)
- UniSTS:308318

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(A) RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cytosolic mRNA polyadenylation	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in polyadenylation-dependent ncRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of TRAMP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Poly(A) RNA polymerase gld-4

NP_492446.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9118115..9123181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060045.7 → NP_492446.3 Poly(A) RNA polymerase gld-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492446.3

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFL0

Conserved Domains (2) summary

cd05402
Location:100 → 213

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:276 → 336

PAP_assoc; Cid1 family poly A polymerase