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clsp-1 Claspin [ Caenorhabditis elegans ]

Gene ID: 172742, updated on 2-Nov-2024

Summary

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Official Symbol
clsp-1
Official Full Name
Claspin
Primary source
WormBase:WBGene00009127
Locus tag
CELE_F25H5.5
See related
AllianceGenome:WB:WBGene00009127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable anaphase-promoting complex binding activity. Predicted to be involved in mitotic DNA replication checkpoint signaling and mitotic G2 DNA damage checkpoint signaling. Located in nucleus. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clsp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (9159896..9163266, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Large ribosomal subunit protein mL54 Neighboring gene Elongation factor 2 Neighboring gene Pyruvate kinase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. Ossareh-Nazari B, et al. G3 (Bethesda), 2016 Oct 13. PMID 27543292, Free PMC Article
  2. Genetic analysis of Caenorhabditis elegans pry-1/Axin suppressors identifies genes involved in reproductive structure development, stress responses, and aging. Mallick A, et al. G3 (Bethesda), 2022 Feb 4. PMID 35100345, Free PMC Article
  3. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
  4. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
  5. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Claspin
NP_001251008.1
  • Confirmed by transcript evidence
NP_001364675.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9159896..9163266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264079.3 → NP_001251008.1  Claspin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251008.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17838

  2. NM_001377615.2 → NP_001364675.1  Claspin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU54
Nucleotide Protein
Heading Accession and Version

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