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pyk-1 Pyruvate kinase [ Caenorhabditis elegans ]

Gene ID: 172744, updated on 2-Nov-2024

Summary

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Official Symbol
pyk-1
Official Full Name
Pyruvate kinase
Primary source
WormBase:WBGene00009126
Locus tag
CELE_F25H5.3
See related
AllianceGenome:WB:WBGene00009126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pyruvate kinase activity. Predicted to be involved in glycolytic process. Predicted to be active in cytoplasm. Is expressed in body wall musculature and reproductive system. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to several human genes including PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pyk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (9168432..9177488)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Claspin Neighboring gene Elongation factor 2 Neighboring gene ncRNA Neighboring gene Plasma membrane proteolipid 3 Neighboring gene ncRNA Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacteria pyruvate metabolism modulates AFB(1) toxicity in Caenorhabditis elegans. Tang B, et al. Sci Total Environ, 2023 Nov 20. PMID 37506907
  2. Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. Yuan Y, et al. J Biol Chem, 2016 Jan 15. PMID 26631730, Free PMC Article
  3. From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. Luz AL, et al. Toxicol Sci, 2016 Aug. PMID 27208080, Free PMC Article
  4. Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans. Dilberger B, et al. Mech Ageing Dev, 2021 Sep. PMID 34139214
  5. An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics. Shaver AO, et al. Front Mol Biosci, 2022. PMID 36438654, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pyruvate kinase
NP_001021412.1
  • Confirmed by transcript evidence
NP_001379415.1
  • Confirmed by transcript evidence
NP_001379495.1
  • Confirmed by transcript evidence
NP_492458.1
  • Confirmed by transcript evidence
NP_492459.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9168432..9177488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060057.7 → NP_492458.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17836
    Conserved Domains (2) summary
    TIGR01064
    Location:78 → 558
    pyruv_kin; pyruvate kinase
    cl23794
    Location:78 → 561
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  2. NM_001026241.7 → NP_001021412.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3S1I8
    Conserved Domains (2) summary
    TIGR01064
    Location:74 → 554
    pyruv_kin; pyruvate kinase
    cl23794
    Location:74 → 557
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  3. NM_001392780.1 → NP_001379495.1  Pyruvate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7WNA0
    Conserved Domains (1) summary
    cd00288
    Location:429 → 912
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  4. NM_001392781.1 → NP_001379415.1  Pyruvate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JL40
    Conserved Domains (1) summary
    cl39076
    Location:47 → 530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  5. NM_060058.5 → NP_492459.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492459.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17835
    Conserved Domains (2) summary
    TIGR01064
    Location:116 → 596
    pyruv_kin; pyruvate kinase
    cl23794
    Location:116 → 599
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein
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