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aspm-1 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172746, updated on 2-Nov-2024

Summary

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Official Symbol
aspm-1
Official Full Name
Calponin-homology (CH) domain-containing protein
Primary source
WormBase:WBGene00008107
Locus tag
CELE_C45G3.1
See related
AllianceGenome:WB:WBGene00008107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity and protein domain specific binding activity. Involved in establishment of meiotic spindle orientation; meiotic spindle organization; and regulation of protein localization. Located in spindle midzone and spindle pole. Used to study microcephaly. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Orthologous to human ASPM (assembly factor for spindle microtubules). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aspm-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (9221818..9226390, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene LIM domain protein;LIM zinc-binding domain-containing protein;Protein espinas Neighboring gene ncRNA Neighboring gene BPL/LPL catalytic domain-containing protein Neighboring gene Gamma-tubulin interacting protein 2 Neighboring gene Gamma-secretase subunit aph-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A microcosm of the biomedical research experience for upper-level undergraduates. Hurd DD. CBE Life Sci Educ, 2008 Summer. PMID 18519612, Free PMC Article
  2. Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1. Connolly AA, et al. Mol Biol Cell, 2014 Apr. PMID 24554763, Free PMC Article
  3. Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro. McNally K, et al. Mol Biol Cell, 2014 Apr. PMID 24501424, Free PMC Article
  4. CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans. Ellefson ML, et al. J Cell Biol, 2011 Jun 27. PMID 21690306, Free PMC Article
  5. ASPM is a major determinant of cerebral cortical size. Bond J, et al. Nat Genet, 2002 Oct. PMID 12355089

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mei-1 and aspm-1 promote oocyte meiotic spindle pole assembly
    Title: Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1.
  2. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles.
    Title: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of meiotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of meiotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of meiotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein
NP_492467.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9221818..9226390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060066.6 → NP_492467.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492467.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17666
    Conserved Domains (2) summary
    smart00015
    Location:959 → 980
    IQ; Calmodulin-binding motif
    smart00033
    Location:353 → 433
    CH; Calponin homology domain
Nucleotide Protein
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