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F14B4.1 EGF-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172750, updated on 2-Nov-2024

Summary

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Official Symbol
F14B4.1
Official Full Name
EGF-like domain-containing protein
Primary source
WormBase:WBGene00008779
Locus tag
CELE_F14B4.1
See related
AllianceGenome:WB:WBGene00008779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F14B4.1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (9265951..9271058, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Sushi domain-containing protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene Phosphotransferase Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EGF-like domain-containing protein
NP_492474.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9265951..9271058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060073.8 → NP_492474.2  EGF-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492474.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFK8
    Conserved Domains (5) summary
    smart00135
    Location:470 → 512
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:663 → 698
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:448 → 486
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:588 → 618
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:272 → 313
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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